Rabbit anti-Glutathione-S-Transferase Polyclonal antibody

Rabbit anti-Glutathione-S-Transferase Polyclonal antibody for WB, ELISA. Suitable for use in Western blot (1:5,000) and ELISA (1:25,000). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Enzymes of the glutathione S-transferase (GST) family are composed of many cytosolic, mitochondrial, and microsomal (now designated as MAPEG) proteins. GSTs are present in eukaryotes and in prokaryotes, where they catalyze a variety of reactions and accept endogenous and xenobiotic substrates. GSTs can constitute up to 10% of cytosolic protein in some mammalian organs. GSTs catalyse the conjugation of reduced glutathione вЂ” via a sulfhydryl group вЂ” to electrophilic centers on a wide variety of substrates. This activity detoxifies endogenous compounds such as peroxidised lipids, as well as breakdown of xenobiotics. GSTs may also bind toxins and function as transport proteins, and, therefore, an early term for GSTs was "ligandin". The mammalian GST super-family consists of cytosolic dimeric isoenzymes of 45вЂ“55 kDa size that have been assigned to at least six classes: Alpha, Mu, Pi, Theta, Zeta and Omega

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts