Rabbit Anti-GSK3A, GSK3B monoclonal antibody, clone TZ37-16

Rabbit Anti-GSK3A, GSK3B monoclonal antibody for WB, ICC, IHC, IP. Glycogen synthase kinase-3? (GSK-3?) and GSK-3? are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3? activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNF? in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3? and GSK-3? induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3? or Ser 9 of GSK-3? and inactivates both forms. GSK-3?/? is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3?/? participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation.

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