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Rabbit Anti-GSK3B monoclonal antibody, clone TZ13-82

Cat no: DCABH-9320

Rabbit Anti-GSK3B monoclonal antibody, clone TZ13-82

Rabbit Anti-GSK3B monoclonal antibody for WB, ICC/IF, IHC, FC. Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer's disease. Two forms of GSK-3, designated GSK-3? and GSK-3?, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer's disease.

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SPECIFICATIONS

Catalog Number

DCABH-9320

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Unconj

Clone

TZ13-82

Target

GSK3B

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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