logo
logo
Rabbit Anti-Human A2M monoclonal antibody, clone KN92-52

Cat no: DCABH-2660

Rabbit Anti-Human A2M monoclonal antibody, clone KN92-52

Rabbit Anti-Human A2M monoclonal antibody for WB, IHC. ?-2-Macroglobulin (?-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, ?-2M was characterized as a pan-proteinase inhibitor that was able to "bait" proteinases into cleaving specific peptide sequences on ?-2M. This interaction induces a conformational change in ?-2M, thus enabling it to "trap" the proteinase and further inhibit its activity. Subsequently, ?-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor ? (TGF?) in serum is primarily bound to ?-2M, which renders TGF? inactive. ?-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding ?-2M are associated with an increased incidence of Alzheimer's Disease (AD), which is consistent with the role of ?-2M in mediating the clearance and degradation of A ?, the major component of ?-Amyloid deposits accumulated during AD.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

DCABH-2660

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KN92-52

Target

A2M

Gene Id

2

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

Read more on Supplier website

SUPPLIER INFO

Latest promotions

Spend less time on DNA cleanup so you can do more science. The MSB Spin PCRapace is the fastest way to purify your DNA from PCR, restriction digestion, and...

Genovis introduces GlycINATOR™• Works on most IgGs• Effective on high-mannose and bisected N-linked Fc-glycans • Rapid – 30-minute...

Use promo code EASY3 to receive 13% off and FREE shipping!Experience a new dimension of electronic pipetting with the NEW Easypet 3 pipette controller. The...

New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...

As an incentive to qualify our BSA, we are offering a 20% discount when you purchase your first 100g, 500g or 1000g of any grade of Bovine Serum Albumin....

It is not every day that you are given something for nothing. We are giving away additional spectrophotometer software.Cecil Instruments have enhanced the...

We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!

For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...

10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...

Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...

Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...

Jenway’s 73 series spectrophotometer range provides four models with a narrow spectral bandwidth of 5nm and an absorbance range of –0.3 to 2.5A,...

Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...