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Rabbit Anti-Human Alas1 monoclonal antibody, clone TB81-15

Rabbit Anti-Human Alas1 monoclonal antibody, clone TB81-15

Cat no: DCABH-4422

Supplier: Creative Diagnostics
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Rabbit Anti-Human Alas1 monoclonal antibody for WB, ICC/IF. 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.
Catalogue number: DCABH-4422
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TB81-15
Gene: 211
Target: Alas1
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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