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Rabbit anti Human APP (N-terminal, aa 1-14) polyclonal antibody

Rabbit anti Human APP (N-terminal, aa 1-14) polyclonal antibody

Cat no: CABT-L521

Supplier: Creative Diagnostics
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Rabbit Anti-Human APP (N-terminal) polyclonal antibody for ELISA, IHC, WB. Amyloid ? (A?) is the peptide that accumulates in the brain in Alzheimer`s disease and certain classes of cerebrovascular angiopathy. Alzheimer`s disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD A?-peptide. A? generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of A? by ?-secretase. The A? peptide is then released by proteolytic cleavage at its C-terminus by g-secretase. The insoluble A? peptide forms aggregates in the vessels and senile plaques of AD brains.
Catalogue number: CABT-L521
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Conjugates: Unconjugated
Gene: 351
Target: APP
Clonality: Polyclonal
Storage temp: Short term: Refrigerate at 4?C; Long term: Freeze at-20?C

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