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Rabbit Anti-Human AR monoclonal antibody, clone TU1564

Cat no: DCABH-2643

Rabbit Anti-Human AR monoclonal antibody, clone TU1564

Rabbit Anti-Human AR monoclonal antibody for WB, ICC/IF, IHC, FC. Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and male reproductive physiology. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind the two biologically active androgens, testosterone (T) and dihydrotestosterone (DHT), with high and nearly identical affinities; however, the rates of association and dissociation of T are about three times more rapid than those of DHT. This difference has resulted in speculation as to whether these differences in binding kinetics could account for the different physiological effects of T and DHT. A striking feature of AR is its rapid degradation in the absence of ligand. It is now well established that androgen binding results in an at least six-fold increase in androgen stability and that ligand-induced stabilization of AR is highly androgen- specific.

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SPECIFICATIONS

Catalog Number

DCABH-2643

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TU1564

Target

AR

Gene Id

367

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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