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Rabbit Anti-Human ATG4B monoclonal antibody, clone 2ID7MD20

Cat no: CABT-L1203

Rabbit Anti-Human ATG4B monoclonal antibody, clone 2ID7MD20

Rabbit Anti-Human ATG4B monoclonal antibody for FC, ICC, IHC-P, IF, WB. Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4b is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.

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SPECIFICATIONS

Catalog Number

CABT-L1203

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Unconj

Clone

2ID7MD20

Target

ATG4B

Gene Id

23192

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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