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Rabbit Anti-Human AXIN1 monoclonal antibody, clone U.729.3

Cat no: CABT-L1205

Rabbit Anti-Human AXIN1 monoclonal antibody, clone U.729.3

Rabbit Anti-Human AXIN1 monoclonal antibody for IHC-P, IP, WB. This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.

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SPECIFICATIONS

Catalog Number

CABT-L1205

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

U.729.3

Target

AXIN1

Gene Id

8312

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

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