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Rabbit Anti-Human c-Abl (phospho Tyr89) monoclonal antibody, clone D.746.0

Cat no: CABT-L1176

Rabbit Anti-Human c-Abl (phospho Tyr89) monoclonal antibody, clone D.746.0

Rabbit Anti-Human c-Abl (phospho Tyr89) monoclonal antibody for ChIP, WB. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

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SPECIFICATIONS

Catalog Number

CABT-L1176

Applications

ChIP

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

D.746.0

Target

ABL1

Gene Id

25

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

SUPPLIER INFO

Creative Diagnostics

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