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Rabbit Anti-Human c-Cbl (phospho Tyr774) monoclonal antibody, clone 9I5M2

Rabbit Anti-Human c-Cbl (phospho Tyr774) monoclonal antibody, clone 9I5M2

Cat no: CABT-L1219

Supplier: Creative Diagnostics
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Rabbit Anti-Human c-Cbl (phospho Tyr774) monoclonal antibody for ICC, IF, WB. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Catalogue number: CABT-L1219
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 9I5M2
Gene: 867
Target: CBL
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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