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Rabbit Anti-Human c-Met (phospho Tyr1349) monoclonal antibody, clone 26I8M7

Cat no: CABT-L1474

Rabbit Anti-Human c-Met (phospho Tyr1349) monoclonal antibody, clone 26I8M7

Rabbit Anti-Human c-Met (phospho Tyr1349) monoclonal antibody for ICC, IF, WB. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

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SPECIFICATIONS

Catalog Number

CABT-L1474

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

26I8M7

Target

MET

Gene Id

4233

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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