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Rabbit Anti-Human Calpastatin monoclonal antibody, clone TQ93

Cat no: DCABH-10841

Rabbit Anti-Human Calpastatin monoclonal antibody, clone TQ93

Rabbit Anti-Human Calpastatin monoclonal antibody for IHC-P. The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death. Calpastatin, a specific endogenous inhibitor of calpain, has a predicted molecular weight of ~77 kDa and an internal repeat of four homologous domains which allow it to inhibit multiple calpain molecules simultaneously. It functions by binding to calpain when calpain binds calcium. When calpastatin is subjected to proteolytic digestion, fragments of calpastatin as small as 15 kDa still retain inhibitory activity.

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SPECIFICATIONS

Catalog Number

DCABH-10841

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TQ93

Target

CAST

Gene Id

831

Isotype

IgG

Clonality

Monoclonal

Storage Temp

4В°C, do not freeze

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