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Rabbit Anti-Human CASP1 polyclonal antibody

Rabbit Anti-Human CASP1 polyclonal antibody

Cat no: CABT-L1706

Supplier: Creative Diagnostics
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Rabbit Anti-Human CASP1 polyclonal antibody for IHC-P. Caspase-1/ICE (Interleukin-1Beta Converting Enzyme) is expressed as a proenzyme of 45kDa in many tissues. Upon stimulus, it gets activated by proteolytic cleavage. Active caspase-1 is a tetramer of two subunits p10 and p20 in 2; 2 proportion. Caspase-1 (cystein aspartic-specific protease 1) cleaves its substrates after an aspartate residue. It cleaves Interleukin Beta into its active form which further exerts its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in fibroblast, which can be inhibited by overexpression of Crm A, a protein from pox virus.
Catalogue number: CABT-L1706
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 834
Target: CASP1
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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