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Rabbit Anti-Human CASP8 polyclonal antibody

Rabbit Anti-Human CASP8 polyclonal antibody

Cat no: CABT-L1707

Supplier: Creative Diagnostics
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Rabbit Anti-Human CASP8 polyclonal antibody for IHC-P. Caspase-8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the proform of the caspase-8 protein. Recruitment of caspase-8 to the Fas receptor results in oligomerization of the caspase-8 protein, which in turn drives its autoactivation through "self-cleavage". Activated caspase-8 then activates other downstream caspases including caspase-9, thereby commiting the cell to undergo apoptosis. This antibody also detects the processed forms (42/44kDa, 25kDA, and 14kDa) of caspase-8.
Catalogue number: CABT-L1707
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 841
Target: CASP8
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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