Rabbit Anti-Human CD146 monoclonal antibody for WB. MUC18, also known as CD146 is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. The protein is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, MUC18 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly.