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Rabbit Anti-Human CD38 monoclonal antibody, clone TO18-31

Cat no: CAB-648RM

Rabbit Anti-Human CD38 monoclonal antibody, clone TO18-31

Rabbit Anti-Human CD38 monoclonal antibody for WB, IHC. CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

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SPECIFICATIONS

Catalog Number

CAB-648RM

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TO18-31

Target

CD38

Gene Id

952

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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