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Rabbit Anti-Human CD3D monoclonal antibody, clone KK19-08

Cat no: DCABH-231

Rabbit Anti-Human CD3D monoclonal antibody, clone KK19-08

Rabbit Anti-Human CD3D monoclonal antibody for WB, ICC, IHC, IP, FC. The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (??), a heterodimer of delta and epsilon chains (??) and a homodimer of two zeta chains (??) or a heterodimer of zeta and eta chains (?h). The ? and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The ?, ? and ? chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the ? chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the ? chain ITAMs has been solved.

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SPECIFICATIONS

Catalog Number

DCABH-231

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KK19-08

Target

CD3D

Gene Id

915

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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