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Rabbit Anti-Human CD80 monoclonal antibody, clone KG21-5

Rabbit Anti-Human CD80 monoclonal antibody, clone KG21-5

Cat no: CABT-L900

Supplier: Creative Diagnostics
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Rabbit Anti-Human CD80 monoclonal antibody for WB, IHC. T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells, bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
Catalogue number: CABT-L900
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: KG21-5
Gene: 941
Target: CD80
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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