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Rabbit Anti-Human CDK4 (phospho Thr172) monoclonal antibody, clone 0I3M8

Cat no: CABT-L1233

Rabbit Anti-Human CDK4 (phospho Thr172) monoclonal antibody, clone 0I3M8

Rabbit Anti-Human CDK4 (phospho Thr172) monoclonal antibody for FC, ICC, IF,. CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.

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SPECIFICATIONS

Catalog Number

CABT-L1233

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

0I3M8

Target

CDK4

Gene Id

1019

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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