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Rabbit Anti-Human CHEK2 monoclonal antibody, clone TD715

Rabbit Anti-Human CHEK2 monoclonal antibody, clone TD715

Cat no: DCABH-9459

Supplier: Creative Diagnostics
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Rabbit Anti-Human CHEK2 monoclonal antibody for WB, ICC/IF, IHC, IP. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.
Catalogue number: DCABH-9459
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TD715
Gene: 11200
Target: CHEK2
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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