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Rabbit Anti-Human Claudin 18 monoclonal antibody, clone 45I25M26

Cat no: CABT-L1246

Rabbit Anti-Human Claudin 18 monoclonal antibody, clone 45I25M26

Rabbit Anti-Human Claudin 18 monoclonal antibody for ICC, IHC-P, IF, WB. Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear. Because of its highly restricted expression pattern in normal tissues and frequent activation in numerous human cancers, claudin-18 may represent an important target for antibody therapy.

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SPECIFICATIONS

Catalog Number

CABT-L1246

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

45I25M26

Target

CLDN18

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Maintain refrigerated at 2-8В°C for up to 1 month. For long term storage store at -20В°C

SUPPLIER INFO

Creative Diagnostics

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