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Rabbit Anti-Human COPS7B Polyclonal Antibody

Cat no: DPABH-08195

Rabbit Anti-Human COPS7B Polyclonal Antibody

Rabbit Anti-Human COPS7B Polyclonal Antibody for IHC, ICC-IF. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

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SPECIFICATIONS

Catalog Number

DPABH-08195

Hosts

Rabbit

Reactivities

Hum

Target

COPS7B

Gene Id

64708

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store at +4В°C for short term storage. Long time storage is recommended at -20В°C. Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

SUPPLIER INFO

Creative Diagnostics

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