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Rabbit Anti-Human COT monoclonal antibody, clone 4I29M6

Rabbit Anti-Human COT monoclonal antibody, clone 4I29M6

Cat no: CABT-L1251

Supplier: Creative Diagnostics
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Rabbit Anti-Human COT monoclonal antibody for WB. COT (Cancer Osaka thyroid oncogene) also known as MAP3K8/TPL2 (Mitogen Activated Protein kinase 8/Tumor Progression Locus 2). This oncogene is a member of the serine threonine protein kinase family and is localized in the cytoplasm. It is known to activate JNK kinase and MAP kinase pathways along with activating IK-B kinases aiding in nuclear production of NF-KappaB. The production of IL-2 and TNFalpha during T cell activation is also mediated by COT/MAP3K8/TPL2. In addition to this, COT/MAP3K8/TPL2 also aids in T-cell costimulation, signal transduction, and amino acid phosphorylation. In humans, the MAP3K8 gene encoding COT/MAP3K8/TPL2 is present on chromosome 10.
Catalogue number: CABT-L1251
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 4I29M6
Gene: 54677
Target: CROT
Isotype: IgG
Clonality: Monoclonal
Storage temp: Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

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