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Rabbit Anti-Human COT monoclonal antibody, clone 4I29M6

Cat no: CABT-L1251

Rabbit Anti-Human COT monoclonal antibody, clone 4I29M6

Rabbit Anti-Human COT monoclonal antibody for WB. COT (Cancer Osaka thyroid oncogene) also known as MAP3K8/TPL2 (Mitogen Activated Protein kinase 8/Tumor Progression Locus 2). This oncogene is a member of the serine threonine protein kinase family and is localized in the cytoplasm. It is known to activate JNK kinase and MAP kinase pathways along with activating IK-B kinases aiding in nuclear production of NF-KappaB. The production of IL-2 and TNFalpha during T cell activation is also mediated by COT/MAP3K8/TPL2. In addition to this, COT/MAP3K8/TPL2 also aids in T-cell costimulation, signal transduction, and amino acid phosphorylation. In humans, the MAP3K8 gene encoding COT/MAP3K8/TPL2 is present on chromosome 10.

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SPECIFICATIONS

Catalog Number

CABT-L1251

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

4I29M6

Target

CROT

Gene Id

54677

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Maintain refrigerated at 2-8В°C for up to 1 month. For long term storage store at -20В°C

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