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Rabbit Anti-Human CTCF monoclonal antibody, clone H.869.5

Cat no: CABT-L1255

Rabbit Anti-Human CTCF monoclonal antibody, clone H.869.5

Rabbit Anti-Human CTCF monoclonal antibody for ChIP, IHC-P, IP, IF, WB. This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. A molecular weight of approximately 140 kDa is expected.

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SPECIFICATIONS

Catalog Number

CABT-L1255

Applications

ChIP

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, Horse

Conjugates

Unconj

Clone

H.869.5

Target

CTCF

Gene Id

10664

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C

SUPPLIER INFO

Creative Diagnostics

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