Rabbit Anti-Human Cullin 2 monoclonal antibody for FC, ICC, IHC-P, IF, WB. In yeast, proteolysis of G1 cell cycle regulatory proteins is controlled by an ubiquitin ligase formed by three subunits: Cdc53 (also known as CulA), Skp1 and one of many F-box proteins. A family of human cullin genes homologous to the S. cerevisiae cdc53 gene has been identified (cul1, 2, 3, 4a, 4b, and 5). In humans Cul2 is part of the ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex which contains the Cullin-RBX module. Human Cul2 does not associate with Skp1 and Skp2. Instead it forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: Elongin C, Elongin B and VHL. The Cul2-Rbx1 module specifically interacts with the VHL box. Intriguingly, Elongin C shows homology with Skp1 and Elongin B with ubiquitin. In its active form, SIII does not contain VHL but rather contains an F box protein, Elongin A.
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