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Rabbit Anti-Human DAXX monoclonal antibody, clone TD65-17

Cat no: CABT-L709

Rabbit Anti-Human DAXX monoclonal antibody, clone TD65-17

Rabbit Anti-Human DAXX monoclonal antibody for WB, ICC, FC. Activation of the cell surface receptor FAS by FAS ligand leads to the initiation of apoptosis, a process necessary for the regulation of the immune system and tissue homeostasis. FAS-mediated apoptosis appears to involve a number of divergent and overlapping pathways. Daxx appears to be a central component of a FAS-mediated apoptotic pathway involving the activation of Jun N-terminal kinase (JNK). Although Daxx itself does not contain a death domain, it specifically binds to the death domain of FAS. Overexpression of Daxx activates the JNK pathway and enhances FAS-mediated apoptosis. The Daxx apoptotic pathway acts cooperatively with but is distinct from the FAS-mediated pathway that involves interactions between the death domain-containing protein FADD and the cysteine protease FLICE. Unlike the FAS-FADD-FLICE pathway, the Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2.

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SPECIFICATIONS

Catalog Number

CABT-L709

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TD65-17

Target

DAXX

Gene Id

1616

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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