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Rabbit Anti-Human DOK1 polyclonal antibody

Rabbit Anti-Human DOK1 polyclonal antibody

Cat no: DCABH-4567

Supplier: Creative Diagnostics
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Rabbit Anti-Human DOK1 polyclonal antibody for IHC-P. DOK-1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK-1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK-1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK-1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
Catalogue number: DCABH-4567
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 1796
Target: DOK1
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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