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Rabbit Anti-Human DR3 monoclonal antibody, clone 22I7M0

Cat no: CABT-L1636

Rabbit Anti-Human DR3 monoclonal antibody, clone 22I7M0

Rabbit Anti-Human DR3 monoclonal antibody for FC, ICC, IF, WB. DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

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SPECIFICATIONS

Catalog Number

CABT-L1636

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Unconj

Clone

22I7M0

Target

TNFRSF25

Gene Id

8718

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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