Rabbit Anti-Human EGFR (phospho Tyr1086) monoclonal antibody for FC, ICC, IF, WB. Epidermal growth factor receptor (EGFR) is encoded by the EGFR gene located on chromosome 7 in humans. It is also known as HER1 (human epidermal growth factor receptor 1) and ERbB1. It belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization. This is followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain due to inherent protein kinase activity of the receptor. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras- ERk, PI3-k- Akt, Jak- STAT and PkC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPk pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling.
Quick Search
Products 
