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Rabbit Anti-Human EZH2 monoclonal antibody, clone KK190-0

Cat no: CABT-L838

Rabbit Anti-Human EZH2 monoclonal antibody, clone KK190-0

Rabbit Anti-Human EZH2 monoclonal antibody for WB, ICC/IF, IHC. In Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. PcG proteins work in conjunction with the trithorax-group (trxG), which activate homeobox gene expression during embryonic development. ENX-1, a mammalian homolog of the Drosophila gene enhancer of zeste, is a PcG protein that is ubiquitously expressed during early embryogenesis and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, ENX-1 is restricted to specific sites, including spleen, testis and placenta. The gene encoding human ENX-1 transcribes a 746 amino acid polypeptide which contains a trithorax-like domain and a DNA-binding motif. ENX-1 interacts with the proto-oncogene product Vav and is thought to be involved in the proliferation of normal and malignant hematopoietic cells. By altering the regulation of target genes, ENX-1 may also contribute to certain phenotypes of Down syndrome.

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SPECIFICATIONS

Catalog Number

CABT-L838

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KK190-0

Target

EZH2

Gene Id

2146

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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