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Rabbit Anti-Human Fas monoclonal antibody, clone KK1053

Cat no: DCABH-1748

Rabbit Anti-Human Fas monoclonal antibody, clone KK1053

Rabbit Anti-Human Fas monoclonal antibody for WB, ICC/IF, IHC, FC. Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.

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SPECIFICATIONS

Catalog Number

DCABH-1748

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

KK1053

Target

Fas

Gene Id

355

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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