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Rabbit Anti-Human FCGR2A monoclonal antibody, clone KN21-81

Rabbit Anti-Human FCGR2A monoclonal antibody, clone KN21-81

Cat no: DCABH-1721

Supplier: Creative Diagnostics
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Rabbit Anti-Human FCGR2A monoclonal antibody for WB, IHC. CD32 (also designated Fc gamma RII) is a low affinity receptor for the Fc fragment of aggregated IgG (1,2). CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells (1-4). IgG can noncooperatively bind either one or two highly glycosylated CD32 molecules, and this binding delivers a negative signal for B cells (1,2,5). CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B, and C (2,6). These isoforms are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC (1,2,6). All isoforms are present on monocytes, placental trophoblasts and endothelial cells (1,6). In addition, the FcgRIIB forms are present on B lymphocytes, and the FcgRIIA and FcgRIIC forms are found on neutrophils (1,6).
Catalogue number: DCABH-1721
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: KN21-81
Gene: 2212
Target: FCGR2A
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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