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Rabbit Anti-Human FOXO3 monoclonal antibody, clone TQ1165

Rabbit Anti-Human FOXO3 monoclonal antibody, clone TQ1165

Cat no: CAB-5583RH

Supplier: Creative Diagnostics
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Rabbit Anti-Human FOXO3 monoclonal antibody for WB, ICC/IF. FKHRL1 (forkhead in rhabdomyosarcoma-like 1), also known as FOXO3 (forkheadbox O3) or FOXO3A, is a 673 amino acid transcriptional activator thatbelongs to the FKHR subfamily of forkhead transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 at Threonine 32 and Serine 253. Phosphorylation by Akt1 negatively regulates FKHRL1 by promoting its export from the nucleus. Phosphorylated FKHRL1 associates with 14-3-3 proteins and this complex is retained in the cytoplasm. Growth factor withdrawal stimulates FKHRL1 dephosphorylation and nuclear translocation, leading to FKHR-induced gene-specific transcriptional activation. Within the nucleus, dephosphorylated FKHRL1 triggers apoptosis by inducing the expression of genes that are critical for cell death.
Catalogue number: CAB-5583RH
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TQ1165
Gene: 2309
Target: FOXO3
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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