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Rabbit Anti-Human Glutamine Synthetase monoclonal antibody, clone 8I0M27

Cat no: CABT-L1329

Rabbit Anti-Human Glutamine Synthetase monoclonal antibody, clone 8I0M27

Rabbit Anti-Human Glutamine Synthetase monoclonal antibody for FC, ICC, IF, WB. Glutamine Synthetase (GS) catalyzes the conversion of ammonia and glutamate to glutamine. This reaction consumes a molecule of ATP: Glutamate + NH4+ + ATP = Glutamine + ADP + Pi. GS is found in astrocytes as an octamer of identical ~45kDa subunits. Most well known function of GS is the detoxification of brain ammonia. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. On the other hands, the level of expression of GS is increased during ischemia in vivo or hypoxia in culture.

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SPECIFICATIONS

Catalog Number

CABT-L1329

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

8I0M27

Target

GS

Gene Id

324

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

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