Rabbit Anti-Human Histone H2B (Acetyl-Lys15) monoclonal antibody for FC, ICC, IF, WB. Histone octamers are an essential component of the nucleosomal complex with key roles in chromatin packaging and target gene transcription. They undergo various post-translational modifications including methylation, acetylation and phosphorylation to facilitate chromatin regulation. These modifications in turn serve as epigenetic markers for transcriptional status of a gene and landing sites for transcriptional complexes. The N-terminal tail of H2B undergoes acetylation regulated by histone acetyl transferases and histone deacetylases. Acetylation of Histone 2B on Lysine 15 (H2Bk15ac) is a chromatin marker associated with actively transcribed genes in cancer cell lines.