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Rabbit Anti-Human Histone H3 (Di-Methyl-Lys9) monoclonal antibody, clone 4I7M5

Cat no: CABT-L1346

Rabbit Anti-Human Histone H3 (Di-Methyl-Lys9) monoclonal antibody, clone 4I7M5

Rabbit Anti-Human Histone H3 (Di-Methyl-Lys9) monoclonal antibody for ChIP, ELISA, FC, ICC, IF, WB. Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Trimethylation of histone H3K9 is associated with heterochromatin formation and gene silencing.

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SPECIFICATIONS

Catalog Number

CABT-L1346

Applications

ChIP, ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

4I7M5

Target

H3K9me2

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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