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Rabbit Anti-Human Histone H3 (Methyl-Lys4) monoclonal antibody, clone 2I5M42

Rabbit Anti-Human Histone H3 (Methyl-Lys4) monoclonal antibody, clone 2I5M42

Cat no: CABT-L1351

Supplier: Creative Diagnostics
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Rabbit Anti-Human Histone H3 (Methyl-Lys4) monoclonal antibody for FC, ICC, IF, WB. Histone octamers are an essential component of the nucleosomal complex with key roles in chromatin packaging and target gene transcription. They undergo various post-translational modifications including methylation, acetylation and phosphorylation to facilitate chromatin regulation. These modifications in turn serve as epigenetic markers for transcriptional status of a gene and landing sites for transcriptional complexes. Methylation of histones is regulated by histone methyl transferases and histone demethylases. Monomethylation of Histone 3 on Lysine 4 (H3K4me1) is a chromatin mark associated with transcriptionally active regions of the chromatin enriched in the H3K27ac mark. It has also been implicated as a marker for 'poised' chromatin state of 'potentially' active genes where it overlaps with H3K27me3 modification.
Catalogue number: CABT-L1351
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 2I5M42
Target: H3K4me1
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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