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Rabbit Anti-Human Histone H4 (Acetyl-Lys8) monoclonal antibody, clone 9I6M5

Rabbit Anti-Human Histone H4 (Acetyl-Lys8) monoclonal antibody, clone 9I6M5

Cat no: CABT-L1381

Supplier: Creative Diagnostics
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Rabbit Anti-Human Histone H4 (Acetyl-Lys8) monoclonal antibody for FC, ICC, IF, WB. Histone octamers are an essential component of the nucleosomal complex with key roles in chromatin packaging and target gene transcription. They undergo various post-translational modifications including methylation, acetylation and phosphorylation to facilitate chromatin regulation. These modifications in turn serve as epigenetic markers for transcriptional status of a gene and landing sites for transcriptional complexes. The N-terminal tail of H4 undergoes acetylation regulated by histone acetyl transferases and histone deacetylases. Acetylated Histone 4 at Lysine 8 (H3k8ac) is typically enriched at positively regulated gene promoters. It is one of the most prominent markers for actively transcribed regions of the chromatin and also has a critical role in transcriptional elongation.
Catalogue number: CABT-L1381
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 9I6M5
Gene: 121504
Target: H4K8Ac
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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