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Rabbit Anti-Human HSD17B10 polyclonal antibody

Rabbit Anti-Human HSD17B10 polyclonal antibody

Cat no: DCABH-5115

Supplier: Creative Diagnostics
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Rabbit Anti-Human HSD17B10 polyclonal antibody for IHC-P. Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB) /L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer's disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer's disease.
Catalogue number: DCABH-5115
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 3028
Target: HSD17B10
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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