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Rabbit Anti-Human HSF1 monoclonal antibody, clone TV42-14

Cat no: DCABH-9992

Rabbit Anti-Human HSF1 monoclonal antibody, clone TV42-14

Rabbit Anti-Human HSF1 monoclonal antibody for WB, ICC, IHC, IP, FC. Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors 1 and 2 (HSF1 and HSF2), also designated HSTF1 and HSTF2, are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer, whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.

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SPECIFICATIONS

Catalog Number

DCABH-9992

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TV42-14

Target

HSF1

Gene Id

3297

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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