Rabbit Anti-Human ID1 monoclonal antibody for WB. There are four members of the Id protein family, Id1, Id2, Id3, and Id4. These proteins were initially discovered as proteins involved in the negative control of cell differentiation. Id proteins act as a negative regulator of transcription through physical interaction with a group of transcription factors known as bHLH (basic helix-loop-helix) proteins. Id proteins interact with bHLH proteins in a manner that prevents DNA binding to the HLH proteins. Because of this activity, the group of proteins were named as Id (for inhibitor of DNA binding). Id proteins have also been found to bind with a number of other proteins such as Rb, Ets, Paz, MIDA-1 and SREBP-1c. Id proteins may play a central role in coordinating gene expression, cell proliferation, tumorigenesis, and angiogenesis. Id proteins have been found to be over-expressed in many types, including Glioblastoma, Medulloblastoma, Neuroblastoma, Pancreatic Cancer, Thyroid Cancer, Squamous Cell Carcinoma, Breast Carcinoma, Endometrial Cancer, Cervical Cancer, Melanoma, and Retinoblastoma. There is a growing body of evidence that Id1 and Id3 play a central role in angiogenesis. Experiments in Id1-/-, Id3-/- knockout mice indicated that with the loss of Id expression there was no vascularization and no subsequent growth of tumors.
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