Rabbit Anti-Human ID3 polyclonal antibody

Cat no: CABT-L1777

Supplier: Creative Diagnostics

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Rabbit Anti-Human ID3 polyclonal antibody for IHC-P. Members of the Id family of basic helix-loop-helix (bHLH) proteins include ID1, ID2, ID3 and ID4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The ID-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since ID1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the ID protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the ID proteins is strongly dependent on growth factor activation and that reduction of ID mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Catalogue number:	CABT-L1777
Reactivities:	Human
Hosts:	Rabbit
Conjugates:	Unconjugated
Gene:	3399
Target:	ID3
Isotype:	IgG
Clonality:	Polyclonal
Storage temp:	2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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Rabbit Anti-Human ID3 polyclonal antibody

Cat no: CABT-L1777

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