Rabbit Anti-Human IGF1R beta (phospho Tyr1135, Tyr1136) monoclonal antibody, clone 26I20M9

Cat no: CABT-L1391

Supplier: Creative Diagnostics

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Rabbit Anti-Human IGF1R beta (phospho Tyr1135, Tyr1136) monoclonal antibody for WB. Insulin growth factor 1 receptor belongs to the family of tyrosine receptor kinases. It is involved in activation of various substrates including IGF and neurotensin, regulation of metabolism, cell division, maintenance, and inflammation response. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation. This antibody recognizes the beta-subunit of IGF1R.

Catalogue number:	CABT-L1391
Reactivities:	Human
Hosts:	Rabbit
Conjugates:	Unconjugated
Clone:	26I20M9
Gene:	3480
Target:	IGF1R
Isotype:	IgG
Clonality:	Monoclonal
Storage temp:	Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

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Rabbit Anti-Human IGF1R beta (phospho Tyr1135, Tyr1136) monoclonal antibody, clone 26I20M9

Cat no: CABT-L1391

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