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Rabbit Anti-Human IKK beta monoclonal antibody, clone K.525.6

Rabbit Anti-Human IKK beta monoclonal antibody, clone K.525.6

Cat no: CABT-L1394

Supplier: Creative Diagnostics
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Rabbit Anti-Human IKK beta monoclonal antibody for WB. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Catalogue number: CABT-L1394
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: K.525.6
Gene: 3551
Target: IKBKB
Isotype: IgG
Clonality: Monoclonal
Storage temp: -20°C

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