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Rabbit Anti-Human IRF8 monoclonal antibody, clone 35I24M30

Rabbit Anti-Human IRF8 monoclonal antibody, clone 35I24M30

Cat no: CABT-L1424

Supplier: Creative Diagnostics
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Rabbit Anti-Human IRF8 monoclonal antibody for ICC, IF, WB. Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-kappa-B by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.
Catalogue number: CABT-L1424
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 35I24M30
Gene: 3394
Target: IRF8
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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