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Rabbit Anti-Human IRS1 (phospho Ser312) monoclonal antibody, clone 29I37M7

Rabbit Anti-Human IRS1 (phospho Ser312) monoclonal antibody, clone 29I37M7

Cat no: CABT-L1427

Supplier: Creative Diagnostics
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Rabbit Anti-Human IRS1 (phospho Ser312) monoclonal antibody for WB. Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm and quote;s tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: IRS-1,2,3, and 4, with IRS-1 being widely expressed.
Catalogue number: CABT-L1427
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Clone: 29I37M7
Gene: 56158
Target: IRS1
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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