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Rabbit Anti-Human ITGAX monoclonal antibody, clone TJ20-17

Cat no: DCABH-2620

Rabbit Anti-Human ITGAX monoclonal antibody, clone TJ20-17

Rabbit Anti-Human ITGAX monoclonal antibody for WB, IHC, IP. Integrin ?X (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with ?2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin ?X/?2 shares similar properties of the ?M/?2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin ?X is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin ?X include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin ?X is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

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SPECIFICATIONS

Catalog Number

DCABH-2620

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TJ20-17

Target

ITGAX

Gene Id

3687

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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