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Rabbit Anti-Human KRT6A monoclonal antibody, clone TO82-18

Cat no: DCABH-4971

Rabbit Anti-Human KRT6A monoclonal antibody, clone TO82-18

Rabbit Anti-Human KRT6A monoclonal antibody for WB, ICC/IF, IHC. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNF? induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP ? transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

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SPECIFICATIONS

Catalog Number

DCABH-4971

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

TO82-18

Target

KRT6A

Gene Id

286887

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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