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Rabbit Anti-Human LATS1 monoclonal antibody, clone 3I54M7

Cat no: CABT-L1448

Rabbit Anti-Human LATS1 monoclonal antibody, clone 3I54M7

Rabbit Anti-Human LATS1 monoclonal antibody for WB. LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

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SPECIFICATIONS

Catalog Number

CABT-L1448

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

3I54M7

Target

LATS1

Gene Id

9113

Isotype

IgG

Clonality

Monoclonal

Storage Temp

-20В°C, Avoid Freeze/Thaw Cycles

SUPPLIER INFO

Creative Diagnostics

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